Two teenage brothers pleaded not guilty to multiple charges in a case in which they and their parents were accused of moving into an elderly man's home and turning it into a hub of drug activity.

Prosecutor Michael J. Walsh said during Cecil Brace's arraignment on Tuesday that the family moved into the Holyoke home of Joseph D. Martin, now 77, five years ago after Martin befriended Cynthia Brace. He said Martin was subjected to five years of filthy living conditions in a house that became a hub of drug activity.

''We have a case of the world's worst houseguests," Walsh said.

He said the Braces ''borrowed" $85,000 from Martin since 2000, and forced him to live in a fetid basement with leaking sewage.