4:33pm: Mr Byrne said Mrs Baden-Clay may have left her house in the early hours of April 20, 2012, in a distressed state.
"What if she decided to go for a walk at that time to clear her heard? What if, because of her depression she takes a Zoloft tablet about 10 or 11pm? That might explain her changing into her walking clothes, which she's found in," Mr Byrne said.
"She leaves the house after placing Gerard's phone on the charger about 1.48am. She walks her usual walk along Boscombe Road and then decides to walk a bit further ... she keeps walking.
"Around 4am the drugs would peak in her blood stream, the medication absorbed in the stomach."
Mr Byrne said Mrs Baden-Clay could have been adversely affected by the increased level of the antidepressant Sertraline in her system that could have cause her to hallucinate.
"And at some time and for some reason she ends up in the river," he said.
"The autopsy can't rule out drowning, it can't rule out a possible fall, or jump from the bridge ...
"That's just a scenario, you may reject it, but it's something you might think is open on the evidence ..
"This trial is a murder trial. It's about you being satisfied beyond reasonable doubt that this man here, for no apparent reason, with no apparent means, managed to kill his wife and dispose of her body."
4:35pm: Court has adjourned for the day.
Mr Byrne will continue his closing address to the jury from 10am tomorrow.
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