This might be TMI, but I thought it might add to the community's understanding of how Alex apparently died.
I almost died from PE a little over five years ago, after weeks of feeling desperately out of breath after very mild exertion. I wrote it off to being "out of shape" due to my sedentary 12-hour workdays.
The morning I called 911, I thought I was having a heart attack. They treated me for that in the ambulance and in the ER until a pulmonary specialist who happened to be there (yay!) noted something in my blood work that tipped her off and ordered my treatment to be changed.
If this is how Alex died, people would have noted that he was easily worn out or "not well" for quite some time before he actually died. No poisons need to have been involved, which is not to say they couldn't have been an additional cause.
Contributing to his cardio-vascular condition, Alex might have had a genetic disorder, as I do, called "Factor V Leiden," which causes thrombophilia, a genetic predisposition to form blood clots. Lifetime use of a "blood thinner" like Eliquis is indicated. In my case, I also opted have an IVC filter inserted to catch and break up any blood clots before they get to the lungs or brain. Doesn't seem like Alex ever went through that level of diagnosis or treatment. Too bad.