What would a biological attack on the U.S. look like? We have a lot of ideas about how that would unfold.
Many people envision bio agents misting out of air vents in public places, or attempts at contamination of water or food sources. Those might produce very small localized outbreaks or infections, but would have little effect other than mass hysteria.
A "real" biological attack would use human vectors in the latent, but highly infectious stage of a moderately deadly airborne infection. (Things like ebola infect and kill too rapidly to be an effective bio weapon, and require contact with the infective agent. And things like adenoviruses wouldn't reliably kill their intended victims.)
Someone or some group with malicious intent could, IMO, quite easily seed a deadly bio agent in all states, regions, and areas fairly easily by using human vectors in the latent phase. No equipment needed. No weapons needed. Just disperse the infected latent human vectors into the general population, ensuring that the human vectors are all in the same stage of latency.
Deadly agents (airborne) with an incubation phase of a few days to a week or so are ideal, as the human vectors will be long gone (dispersed or recalled by the nefarious organizers) before the newly infected victims begin showing symptoms. Thus, making it more difficult to locate infectious vectors.
Once a critical "mass" of the population are infected, it will be impossible to quarantine enough people to stop the spread. We don't have enough medical resources (or willing health care providers) to care for large swaths of the population-- and most health care workers will be rapidly infected in the first wave of victims.
Anyway, enough doom and gloom. Yes, bio warfare is definitely possible.
This is an old book, but it is a good primer on deadly infectious disease for anyone interested. (Warning-- the content may keep you up at night worrying.)
https://www.amazon.com/Coming-Plagu...=1540844598&sr=8-2&keywords=the+coming+plague
Here's another very scary book:
https://www.amazon.com/Biohazard-Ch...F8&qid=1540845806&sr=8-1&keywords=bio+warfare