AJ went from 80% chance of getting Breast cancer to 5% after the manstectomy
My grandmother died of breast cancer at a young age to,no preventive meds back then
My sister who is mentally challenged had it 3 yrs ago & they had to remove her left breast,she has been cancer free ever since
My doctor told me-most times the cancer skips generations,so I prolly won't get it
But my daughter who is 25 has a good chance of getting it
I don't know how true this is,but I am scared for both of us.
I think what AJ did was brave & smart thing to do!!
Wish I could afford the test!!!
I don't think that cancer skips generations as a rule. Many cancers are more random or sporadic than genetic, and a person's chances of getting it are not much affected by their relatives, other than to the extent they may share some common risk factors in terms of similar nutrition, the same living environment, similar habits that increase or decrease cancer risk.
In cases of hereditary cancers it may sometimes appear to skip a generation because what is inherited is merely a gene that increases your risk of cancer but it does not mean that you will definitely get the disease. In any family, it is quite possible that some generations will be lucky and not get it, and others are more unlucky. But once someone has the mutation, the effects of the gene are not dependent on whether or not there were any diseases in the previous generations.
Diseases that truly skip generations are usually inherited so that heterozygous carriers don't get sick but if some of their descendants get the same mutation from both parents (homozygous) they will get the disease, or in the X chromosome so that boys who only have one X chromosome are ill and their mothers and daughters are just carriers because they have two X chromosomes.
Then there are of course some diseases that may appear to "skip a generation" because there are only males or females in a generation and the risk is different in males and females. Breast cancer is more common in women and no women have ever died of prostate cancer that I know of, that sort of thing.
Supposing for a moment that your grandmother's and sister's cancer was hereditary, it does not really make sense to me to say that your daughter has a greater chance of getting the same mutation than you. This is because your daughter is a generation farther from your grandmother than you are. There is a chance that you did not inherit the mutation from your parent even if your sister did. If you did not, your daughter hasn't got it either. Even if you did inherit the mutation from your parent, there is still a chance that your daughter did not inherit it from you and does not have it. (This is assuming that the gene is just on your grandmother's side of the family and any of the spouses didn't have it.)