Years ago when you could buy chloroform at any pharmacy without prescription my best friends mother was hooked on it. We had to go to pharmacys all over to get it for her so she could get high on it. Many times I saw the cloth to her mouth, inhaling it. Sometimes all day. And, never was there any marks on her mouth or inside her mouth.
Eventually you had to start signing for it and then it got so that we couldn't get it for her at all. I never saw her go into fits. And, believe me, this woman would hold that stuff to her face for very long times. Telling my best friend she had to fly around the room was about the only "fit" she had.