Apologies again if you thought I said she WAS depressed because of being obese, I said "Perhaps." Anything is possible... I was thinking out loud and typing hypotheticals on what was known, isn't known (I had no idea about labels so perhaps the KCME knows if she had Canadian toothpaste or American toothpaste - that was not revealed) and what could be. I know laxatives are taken many times either because of symptoms or for eating disorders. She may have been dandy with her weight, for all we know. She had nice things, but I don't know that she took good care of herself - she was taking medication for something - perhaps genetic, perhaps as a result of her weight: HBP, or thyroid issues... But a decrease in water, through overuse of laxatives IF she did that due to having an eating disorder like binging , and the use of cyanide which deprives heart and brain of oxygen (water and oxygen are essential for the heart and brain) would certainly seal her doom and remove any doubt she had about the cyanide being effective - she did a very good job of shutting her body down quickly imo of course, and always not an absolute as no one knows... well the KCME knows if she probably had thyroid issues, or an eating disorder they weigh everything out during an autopsy. If there were any abnormalities they would have caught it...however with depravation of oxygen comes tissue death, so at least the stomach and part of the upper intestine would have degraded pretty well in 2 days time when she was discovered, as well as her heart. I'm not sure how they allow for poison's in damaged organs combined with decomposition... I'm sure it's fascinating to measure these things and research with temperature, time, amount of poison in the system, blood samples looking at fluids in the body, viewing stomach contents and intestines to see what was last consumed, what deficiencies could be shown, etc... I'm a licensed phlebotomist and medical assistant and only deal with living tissues and samples in OB/GYN as well as family medicine, so living is where my knowledge stops.